… However, in this study three adaptive trajectories shown to stabilize a conjugative drug
resistance … common patterns of plasmid-host coevolution that can stabilize antibiotic resistance in …

… stabilizing factor is host–plasmid coevolution under antibiotic … We then asked how plasmid–host
coevolution would affect … drug resistance plasmids after a short period of coevolution …

… However, in this study three adaptive trajectories shown to stabilize a conjugative drug
resistance … common patterns of plasmid-host coevolution that can stabilize antibiotic resistance in …

… Our results provide insights into genetic mechanisms stabilizing plasmids during evolution.
… Another key implication of our results is that evolutionary stabilization of plasmids is host …

… and inappropriate use of antibiotics has fuelled the spread of antibiotic resistance (AR) … of
a post-antibiotic era i–iv . As a result, every year more people die from resistant infections, and …

… Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance. Sci Rep …
Adaptive modulation of antibiotic resistance through intragenomic coevolution. Nat Ecol Evol …

… According to our expectation, the plasmid host frequency in a mixed … 1d) the plasmid host
dynamics appeared different among the … However, plasmid host proportions stabilized after ~50 …

… that contribute to interspecies dissemination of antimicrobial resistance (AMR) genes. …
plasmids [55], and plasmid-host co-evolution often results in plasmid stabilisation [56]. Our …

… was described, new data and theory … pattern has been independently observed in
diverse collections of E. coli environmental and clinical isolates for unrelated antibiotic-resistance …

… Frequent horizontal gene transfer and chromosomal integration events illustrate the
pronounced impact of coevolution with these extrachromosomal elements on bacterial genome …