Enantioresolution and absolute stereochemistry of 2-(1-naphthyl) propane-1, 2-diol and related compounds
S Kuwahara, K Fujita, M Watanabe, N Harada, T Ishida - Enantiomer, 1999 - hero.epa.gov
The method using chiral phthalic acid amide (1) or (2) was applied to make the
enantioresolution of 2-(1-naphthyl) propane-1, 2-diol (3) giving (-)-enantiopure diol 3, the S
absolute configuration of which was unambiguously determined by X-ray crystallography of
its p-bromobenzoate (-)-(7). The S absolute configurations of 2-methoxy-2-(1-naphthyl)-
propionic acid (+)-(4) and related compounds were also determined by chemical correlation
to diol (S)-(-)-3.
enantioresolution of 2-(1-naphthyl) propane-1, 2-diol (3) giving (-)-enantiopure diol 3, the S
absolute configuration of which was unambiguously determined by X-ray crystallography of
its p-bromobenzoate (-)-(7). The S absolute configurations of 2-methoxy-2-(1-naphthyl)-
propionic acid (+)-(4) and related compounds were also determined by chemical correlation
to diol (S)-(-)-3.
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