While the links between metabolic dysfunction associated steatotic liver disease liver
disease (MASLD) and obesity, insulin resistance are widely appreciated, there are a host of
complex interactions between the liver and other endocrine axes. While it can be difficult to
definitively distinguish direct causal relationships and those attributable to increased
adipocyte mass, there is substantial evidence of direct and indirect specific endocrine
dysregulation and severity of MASLD. Strong evidence of direct and indirect effects exists for …