Engineered CAR-macrophages as adoptive immunotherapies for solid tumors

C Sloas, S Gill, M Klichinsky - Frontiers in immunology, 2021 - frontiersin.org
Cellular immunotherapies represent a promising approach for the treatment of cancer.
Engineered adoptive cell therapies redirect and augment a leukocyte's inherent ability to
mount an immune response by introducing novel anti-tumor capabilities and targeting
moieties. A prominent example of this approach is the use of T cells engineered to express
chimeric antigen receptors (CARs), which have demonstrated significant efficacy against
some hematologic malignancies. Despite increasingly sophisticated strategies to harness …

[引用][C] Engineered CAR-macrophages as adoptive immunotherapies for solid tumors. Front Immunol. 2021; 12: 783305

C Sloas, S Gill, M Klichinsky - 2021
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