Enhanced AMPA receptor-mediated excitatory transmission in the rodent rostromedial tegmental nucleus following lesion of the nigrostriatal pathway
Y Chang, C Du, L Han, S Lv, J Zhang, G Bian… - Neurochemistry …, 2019 - Elsevier
The GABAergic rostromedial tegmental nucleus (RMTg) has reciprocal connections with the
dopaminergic ventral tegmental area and substantia nigra pars compacta (SNc), and is
involved in inhibitory control of monoaminergic nuclei. At present, it is not clear whether
unilateral 6-hydroxydopamine lesions of the SNc in rats affect AMPA receptor-mediated
excitatory transmission in the RMTg. Here we found that lesions of the SNc in rats increased
the firing rate of GABAergic neurons and the level of glutamate in the RMTg compared to …
dopaminergic ventral tegmental area and substantia nigra pars compacta (SNc), and is
involved in inhibitory control of monoaminergic nuclei. At present, it is not clear whether
unilateral 6-hydroxydopamine lesions of the SNc in rats affect AMPA receptor-mediated
excitatory transmission in the RMTg. Here we found that lesions of the SNc in rats increased
the firing rate of GABAergic neurons and the level of glutamate in the RMTg compared to …
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