Enhanced biotransformation of the minor ginsenosides in red ginseng extract by Penicillium decumbens β-glucosidase
SY Kim, HN Lee, SJ Hong, HJ Kang, JY Cho… - Enzyme and Microbial …, 2022 - Elsevier
Abstract Compound K (CK) and Rh2, which are present at low levels in ginseng and
ginseng extracts, have higher intestinal absorption rates than other ginsenosides. Here, we
attempted to convert ginsenoside Rb1 to CK using a β-glucosidase from Penicillium
decumbens. Ten commercially available enzymes were screened to identify enzymes that
can convert ginsenoside Rb1 to CK, resulting in the selection of a P. decumbens-derived β-
glucosidase. β-Glucosidase showed maximum activity at pH 4.0 and 60° C; its substrate …
ginseng extracts, have higher intestinal absorption rates than other ginsenosides. Here, we
attempted to convert ginsenoside Rb1 to CK using a β-glucosidase from Penicillium
decumbens. Ten commercially available enzymes were screened to identify enzymes that
can convert ginsenoside Rb1 to CK, resulting in the selection of a P. decumbens-derived β-
glucosidase. β-Glucosidase showed maximum activity at pH 4.0 and 60° C; its substrate …
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