Enhanced pneumocystis carinii activity of new primaquine analogues
TE Goodwin, CJ Boylan, WL Current, JC Byrd… - Bioorganic & medicinal …, 2000 - Elsevier
Bioorganic & medicinal chemistry letters, 2000•Elsevier
New analogues of the venerable antimalarial drug primaquine have been synthesized and
bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among
immunosuppressed patients. Two of these new compounds are significantly more active
than primaquine itself, and provide new information for future drug design and development
in this area.
bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among
immunosuppressed patients. Two of these new compounds are significantly more active
than primaquine itself, and provide new information for future drug design and development
in this area.
New analogues of the venerable antimalarial drug primaquine have been synthesized and bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among immunosuppressed patients. Two of these new compounds are significantly more active than primaquine itself, and provide new information for future drug design and development in this area.
Elsevier
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