Enhanced therapeutic anti-inflammatory effect of betamethasone on topical administration with low-frequency, low-intensity (20 kHz, 100 mW/cm2) ultrasound …
The purpose of this work was to investigate whether low-frequency, low-intensity (20 kHz,<
100 mW/cm 2, spatial-peak, temporal-peak intensity) ultrasound, delivered with a lightweight
(< 100 g), tether-free, fully wearable, battery-powered applicator, is capable of reducing
inflammation in a mouse model of rheumatoid arthritis. The therapeutic, acute, anti-
inflammatory effect was estimated from the relative swelling induced in mice hindlimb paws.
In an independent, indirect approach, the inflammation was bio-imaged by measuring …
100 mW/cm 2, spatial-peak, temporal-peak intensity) ultrasound, delivered with a lightweight
(< 100 g), tether-free, fully wearable, battery-powered applicator, is capable of reducing
inflammation in a mouse model of rheumatoid arthritis. The therapeutic, acute, anti-
inflammatory effect was estimated from the relative swelling induced in mice hindlimb paws.
In an independent, indirect approach, the inflammation was bio-imaged by measuring …
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