The rapid pace of cell type identification by new single-cell analysis methods has not been
met with efficient experimental access to the newly discovered types. To enable flexible and
efficient access to specific neural populations in the mouse cortex, we collected chromatin
accessibility data from individual cells and clustered the single-cell data to identify
enhancers specific for cell classes and subclasses. When cloned into adeno-associated
viruses (AAVs) and delivered to the brain by retro-orbital injections, these enhancers drive …