Giant reed is an aggressive agricultural species with remarkable reproductive abilities allows it to out compete native species of plants for land and food resources. In this study, a novel application of giant reed ash (GRA) to partially replace the fine aggregate by 2.5, 5.0, 7.5, 10.0, and 12.5% in concrete mixes was investigated. The influence of giant reed on the fundamental mechanical properties of concrete mixes was analyzed. Curing ages of 7, 14, and 28 days were applied in this study. Results revealed an increase in the compressive and flexural strengths up to 7.96 and 7.28%, respectively when giant reed replaced the sand by 7.5% by weight. From environmental perspective, the results confirmed that using GRA offers a sustainable approach to solve the pollution problems arise from the accumulation of this excessive aggressive species in the production sites; in the meantime modified properties were added to the concrete.