Enzymatic control over reactive intermediates enables direct oxidation of alkenes to carbonyls by a P450 iron-oxo species
The aerobic oxidation of alkenes to carbonyls is an important and challenging
transformation in synthesis. Recently, a new P450-based enzyme (aMOx) has been evolved
in the laboratory to directly oxidize styrenes to their corresponding aldehydes with high
activity and selectivity. The enzyme utilizes a heme-based, high-valent iron-oxo species as a
catalytic oxidant that normally epoxidizes alkenes, similar to other catalysts. How the
evolved aMOx enzyme suppresses the commonly preferred epoxidation and catalyzes direct …
transformation in synthesis. Recently, a new P450-based enzyme (aMOx) has been evolved
in the laboratory to directly oxidize styrenes to their corresponding aldehydes with high
activity and selectivity. The enzyme utilizes a heme-based, high-valent iron-oxo species as a
catalytic oxidant that normally epoxidizes alkenes, similar to other catalysts. How the
evolved aMOx enzyme suppresses the commonly preferred epoxidation and catalyzes direct …
Enzymatic Control over Reactive Intermediates Enables Direct Oxidation of Alkenes to Carbonyls by a P450 Iron-Oxo Species
J Soler i Parpal, S Gergel, C Klaus… - Journal of the …, 2022 - dugi-doc.udg.edu
The aerobic oxidation of alkenes to carbonyls is an important and challenging
transformation in synthesis. Recently, a new P450-based enzyme (aMOx) has been evolved
in the laboratory to directly oxidize styrenes to their corresponding aldehydes with high
activity and selectivity. The enzyme utilizes a heme-based, high-valent iron-oxo species as a
catalytic oxidant that normally epoxidizes alkenes, similar to other catalysts. How the
evolved aMOx enzyme suppresses the commonly preferred epoxidation and catalyzes direct …
transformation in synthesis. Recently, a new P450-based enzyme (aMOx) has been evolved
in the laboratory to directly oxidize styrenes to their corresponding aldehydes with high
activity and selectivity. The enzyme utilizes a heme-based, high-valent iron-oxo species as a
catalytic oxidant that normally epoxidizes alkenes, similar to other catalysts. How the
evolved aMOx enzyme suppresses the commonly preferred epoxidation and catalyzes direct …
以上显示的是最相近的搜索结果。 查看全部搜索结果