Accidents involving poisonous animals in southern Santa Catarina State, Brazil, from 1994 to 2005 were evaluated with the aim of verifying their frequency through the analysis of 2,625 victim’s reports involving poisonous animals from the SINAN (System of Injury Notification Information) files of the Municipal Health Secretary of the AMESC and AMREC microregions, formed by 27 municipalities. Statistical analysis was performed using the chi-square exact test to verify similarities between the AMREC and AMESC microregions, where p values ≤0.05 were considered significant. The results demonstrated that: 52.95% (n = 1,390) of occurrences involved spiders, 18.13% (n = 476) snakes, 5.00% (n = 131) bees, 2.29% (n = 60) caterpillars, 1.41% (n = 37) scorpions, 5.45% (n = 143) other animals and 14.78% (n = 388) unknown. The anatomic region that suffered the most bites was the feet 16.11% (n = 444). Accidents were more frequent in men 54.64% (n = 1.437) than in women 45.25% (n = 1,188). In only 1.18% (n = 31) of cases did recovery present sequelae. The months presenting the highest number of recorded cases were October through March, spring and summer in Brazil. The high frequency of victim recuperation suggests that the public health system is efficient, and the low frequency of recovered victims with sequelae also suggests that this system is fast and well-adjusted. However, there may have been deficiencies in the epidemiologic information system.