Epigenetic identity in AML depends on disruption of nonpromoter regulatory elements and is affected by antagonistic effects of mutations in epigenetic modifiers
JL Glass, D Hassane, BJ Wouters, H Kunimoto… - Cancer discovery, 2017 - AACR
We performed cytosine methylation sequencing on genetically diverse patients with acute
myeloid leukemia (AML) and found leukemic DNA methylation patterning is primarily driven
by nonpromoter regulatory elements and CpG shores. Enhancers displayed stronger
differential methylation than promoters, consisting predominantly of hypomethylation. AMLs
with dominant hypermethylation featured greater epigenetic disruption of promoters,
whereas those with dominant hypomethylation displayed greater disruption of distal and …
myeloid leukemia (AML) and found leukemic DNA methylation patterning is primarily driven
by nonpromoter regulatory elements and CpG shores. Enhancers displayed stronger
differential methylation than promoters, consisting predominantly of hypomethylation. AMLs
with dominant hypermethylation featured greater epigenetic disruption of promoters,
whereas those with dominant hypomethylation displayed greater disruption of distal and …
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