… of human heartdevelopment and the heart defects known to … of epigenetics and mechanobiology in normal development and in … in the identification of novel epigenetic biomarkers …
SR Martinez, MS Gay, L Zhang - Drug discovery today, 2015 - Elsevier
… of epigenetic mechanisms in heartdevelopment as well as aberrant epigenetic regulation … Additionally, we will address recent advances targeting epigenetic mechanisms as potential …
… These findings thus suggest a causal role of Brg1-mediated chromatin regulation in the pathogenesis of adult cardiomyopathy and an epigenetic link between fetal heartdevelopment …
T Moore-Morris, PP van Vliet… - Physiological …, 2018 - journals.physiology.org
… We have overviewed the basic knowledge of epigenetic regulation of heartdevelopment. We further described cardiac congenital diseases associated with epigenetic dysfunction. …
L Linglart, D Bonnet - Journal of Cardiovascular Development and …, 2022 - mdpi.com
… of the anomalous heartdevelopment is still unclear in most … heart relies on timed activation of developmental molecular cascades, spatially and temporally regulated through epigenetic …
… While genetics has significantly contributed to our understanding of different human diseases, the effects of epigenetics on the development and progression on these diseases are not …
T Nührenberg, R Gilsbach, S Preissl, T Schnick… - Cell and tissue …, 2014 - Springer
… Substantial new knowledge has accrued, over the past few years, concerning the epigenetic regulation of heartdevelopment and disease. Epigenetic mechanisms comprise DNA …
G Wang, B Wang, P Yang - Journal of the American Heart …, 2022 - Am Heart Assoc
… research data of epigenetic modifications in heartdevelopment and CHD to identify highly specific and reliable epigenetic biomarkers and to establish epigenetics‐based therapeutics …
BN Akerberg, WT Pu - Cold Spring Harbor perspectives …, 2020 - cshperspectives.cshlp.org
… NuRD), and Polycomb epigenetic regulatory complexes in heartdevelopment. The mammalian heart develops through an intricate dance that transforms the linear heart tube into a four-…