Epithelial cell death markers in bronchoalveolar lavage correlate with chronic lung allograft dysfunction subtypes and survival in lung transplant recipients—a single …
Chronic lung allograft dysfunction (CLAD) remains the leading cause of late death after lung
transplantation. Epithelial injury is thought to be a key event in the pathogenesis of CLAD.
M30 and M65 are fragments of cytokeratin‐18 released specifically during epithelial cell
apoptosis and total cell death, respectively. We investigated whether M30 and M65 levels in
bronchoalveolar lavage (BAL) correlate with CLAD subtypes: restrictive allograft syndrome
(RAS) versus bronchiolitis obliterans syndrome (BOS). BAL s were obtained from 26 patients …
transplantation. Epithelial injury is thought to be a key event in the pathogenesis of CLAD.
M30 and M65 are fragments of cytokeratin‐18 released specifically during epithelial cell
apoptosis and total cell death, respectively. We investigated whether M30 and M65 levels in
bronchoalveolar lavage (BAL) correlate with CLAD subtypes: restrictive allograft syndrome
(RAS) versus bronchiolitis obliterans syndrome (BOS). BAL s were obtained from 26 patients …
Epithelial Cell Death Markers in Bronchoalveolar Lavage Correlate with Chronic Lung Allograft Dysfunction Phenotypes
L Levy, A Tigert, S Moshkelgoshal, B Joe… - The Journal of Heart …, 2018 - jhltonline.org
Purpose Chronic lung allograft dysfunction (CLAD) remains the main hurdle for long-term
survival after lung transplantation (LTx). Chronic epithelial injury is thought to be a final
common pathway in the pathogenesis of CLAD. M30 and M65 are fragments of cytokeratin
18 released during epithelial cell apoptosis and combined apoptosis-necrosis, respectively.
We aimed to examine whether M30 and M65 in early post-LTx BAL may predict CLAD and
whether their levels in BAL obtained at the time of CLAD diagnosis correlate with the major …
survival after lung transplantation (LTx). Chronic epithelial injury is thought to be a final
common pathway in the pathogenesis of CLAD. M30 and M65 are fragments of cytokeratin
18 released during epithelial cell apoptosis and combined apoptosis-necrosis, respectively.
We aimed to examine whether M30 and M65 in early post-LTx BAL may predict CLAD and
whether their levels in BAL obtained at the time of CLAD diagnosis correlate with the major …
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