Escherichia coli α-hemolysin triggers shrinkage of erythrocytes via KCa3. 1 and TMEM16A channels with subsequent phosphatidylserine exposure
M Skals, UB Jensen, J Ousingsawat… - Journal of Biological …, 2010 - ASBMB
α-Hemolysin from Escherichia coli (HlyA) readily lyse erythrocytes from various species. We
have recently demonstrated that this pore-forming toxin provokes distinct shrinkage and
crenation before it finally leads to swelling and lysis of erythrocytes. The present study
documents the underlying mechanism for this severe volume reduction. We show that HlyA-
induced shrinkage and crenation of human erythrocytes occur subsequent to a significant
rise in [Ca 2+] i. The Ca 2+-activated K+ channel K Ca 3.1 (or Gardos channel) is essential …
have recently demonstrated that this pore-forming toxin provokes distinct shrinkage and
crenation before it finally leads to swelling and lysis of erythrocytes. The present study
documents the underlying mechanism for this severe volume reduction. We show that HlyA-
induced shrinkage and crenation of human erythrocytes occur subsequent to a significant
rise in [Ca 2+] i. The Ca 2+-activated K+ channel K Ca 3.1 (or Gardos channel) is essential …
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