Proper regulation of the bacterial cell envelope is critical for cell survival. Identification and
characterization of enzymes that maintain cell envelope homeostasis is crucial, as they can
be targets for effective antibiotics. In this study, we have identified a novel enzyme, called
EstG, whose activity protects cells from a variety of lethal assaults in the⍺-proteobacterium
Caulobacter crescentus. Despite homology to transpeptidase family cell wall enzymes and
an ability to protect against cell wall-targeting antibiotics, EstG does not demonstrate …

Proper regulation of the bacterial cell envelope is critical for cell survival. Identification and
characterization of enzymes that maintain cell envelope homeostasis is crucial, as they can
be targets for effective antibiotics. In this study, we have identified a novel enzyme, called
EstG, whose activity protects cells from a variety of lethal assaults in the⍺-proteobacterium
Caulobacter crescentus. Despite homology to transpeptidase family cell wall enzymes and
an ability to protect against cell-wall-targeting antibiotics, EstG does not demonstrate …