Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells
K Hisamoto, M Ohmichi, H Kurachi, J Hayakawa… - Journal of Biological …, 2001 - ASBMB
Although estrogen is known to activate endothelial nitric oxide synthase (eNOS) in the
vascular endothelium, the molecular mechanism responsible for this effect remains to be
elucidated. In studies of both human umbilical vein endothelial cells (HUVECs) and simian
virus 40-transformed rat lung vascular endothelial cells (TRLECs), 17β-estradiol (E2), but
not 17α-E2, caused acute activation of eNOS that was unaffected by actinomycin D and was
specifically blocked by the pure estrogen receptor antagonist ICI-182,780. Treatment of both …
vascular endothelium, the molecular mechanism responsible for this effect remains to be
elucidated. In studies of both human umbilical vein endothelial cells (HUVECs) and simian
virus 40-transformed rat lung vascular endothelial cells (TRLECs), 17β-estradiol (E2), but
not 17α-E2, caused acute activation of eNOS that was unaffected by actinomycin D and was
specifically blocked by the pure estrogen receptor antagonist ICI-182,780. Treatment of both …
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