Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats
W Zhang, H Wu, Q Xu, S Chen, L Sun, C Jiao… - Biology of sex …, 2020 - Springer
Estrogen plays substantial roles in pain modulation; however, studies concerning sex
hormones and nociception often yield confusing results. The discrepancy could be a result
of lack of consensus to regard estrogen as a variable when working with animal models;
thus, the influence of hormones' fluctuations on nociception has continually been neglected.
In the present study, we designed a novel hormone substitution model to aid us to evaluate
the effects of estrogen's long-term alterations on ovariectomy (OVX)-induced mechanical …
hormones and nociception often yield confusing results. The discrepancy could be a result
of lack of consensus to regard estrogen as a variable when working with animal models;
thus, the influence of hormones' fluctuations on nociception has continually been neglected.
In the present study, we designed a novel hormone substitution model to aid us to evaluate
the effects of estrogen's long-term alterations on ovariectomy (OVX)-induced mechanical …
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