… In light of the need to consider ethical issues proactively as a part of epidemic preparedness,
we use the case of a Zika virus HCT to explore whether and when HCTs might be ethically …

… are both scientific and ethical reasons to consider conducting … , the results of separate human
challenge studies helped (i) … in discussion of potential HCS with Zika virus(10); whether or …

… for the Virus Zika virus has been isolated from brain tissues of human fetuses with … The
virus may be transferred via placental infection or by passage across the placenta (15), followed …

… (i) areas of consensus regarding ethical issues and regulation in the context of LMIC HCS,
as well as (ii) unresolved … Zika virus infection experimentally induced in a human volunteer. …

… Ethical Considerations for Zika Virus Challenge Trials does mention possible benefits of this
kind for challenge … workshop: An ethical framework for human challenge studies, organized …

… Zika virus epidemic, the proposed human challenge studies … of an ethics consultation that
highlighted concerns regarding … Lessons from the case of a Zika virus human challenge trial. …

… , and human challenge trials) are clinical studies that provide a … For the Zika virus (ZIKV), an
initial ethical review panel … a challenge model can be used to solve certain ethical issues in …

… review of specific protocols for Zika human challenge trials (HCTs), … knowledge about Zika
virus. However, comprehensive … ethical considerations related to a potential program of Zika …

… The development of such models needs the participation of volunteers that require approval
by appropriate regulatory bodies, which should take into consideration the ethical issues as …

… on ethical guidance for human challenge studies which is likely … for ethical considerations
for those planning human infection … discussions around human challenge studies for Zika virus […