An ethnobotanical survey was conducted from September to December 2013 in the Sekyere Central district of the Ashanti region of Ghana. The survey aimed at identifying the plants used in the treatment of malaria in the Sekyere central district of Ashanti region of Ghana. The survey involved use of questionnaires and interviews with herbalist, house–to-house and the field that have a rich knowledge on the plants. A total of 29 medicinal plants species were recorded from the survey. To compare the usages of the plant species, an index of performance (Ip) was calculated for each plant species, from the number of citations of treatment actually recorded from the households against the proportion of each plant among the general flora. The survey revealed that, 6 of the 29 species of plants identified have not been authenticated for its antimalarial activity. Afzelia africana, Antrocaryon micraster, Afraegle paniculata, Persea americana and Antiaris africana spp. and Panda oleosa. The remaining 23 species have gone through various degrees of scientific authentications and validations.