Evaluating the impact of Viola spathulata in a rat model of brain ischemia/reperfusion by influencing expression level of caspase-3 and cyclooxygenase-2
M Ramezanpour, K Khanaki, M Faezi… - Physiology and …, 2022 - ppj.phypha.ir
Physiology and Pharmacology, 2022•ppj.phypha.ir
Results: IV and NDS in MCAO rats were remarkably higher compared with normal control
rats and pre-treatment with V. spathulata extracts markedly reduced IV and NDS in the core,
penumbra and subcortical regions of MCAO rats. Also, the level of COX2 and CASP3 mRNA
was higher in the MCAO control group relative to normal control. Pre-treatment with V.
spathulata extracts markedly reduced CASP3 mRNA relative to MCAO rats. Conclusion: It
was found that V. spathulata might reduce ischemic damage in the brain of MCAO rats partly …
rats and pre-treatment with V. spathulata extracts markedly reduced IV and NDS in the core,
penumbra and subcortical regions of MCAO rats. Also, the level of COX2 and CASP3 mRNA
was higher in the MCAO control group relative to normal control. Pre-treatment with V.
spathulata extracts markedly reduced CASP3 mRNA relative to MCAO rats. Conclusion: It
was found that V. spathulata might reduce ischemic damage in the brain of MCAO rats partly …
Results: IV and NDS in MCAO rats were remarkably higher compared with normal control rats and pre-treatment with V. spathulata extracts markedly reduced IV and NDS in the core, penumbra and subcortical regions of MCAO rats. Also, the level of COX2 and CASP3 mRNA was higher in the MCAO control group relative to normal control. Pre-treatment with V. spathulata extracts markedly reduced CASP3 mRNA relative to MCAO rats. Conclusion: It was found that V. spathulata might reduce ischemic damage in the brain of MCAO rats partly by decreasing apoptotic effects of CASP3. Further research is recommended to investigate signaling pathways involved in apoptosis. www. phypha. ir/ppj
ppj.phypha.ir
以上显示的是最相近的搜索结果。 查看全部搜索结果