[PDF][PDF] Evaluation of acute oral toxicity induced by n-hexane extract of Leptadenia hastata Leaves in wistar rats

M Attah, T Jacks, SH Garba, NI Dibal… - Int J Veterina Sci Animal …, 2019 - researchgate.net
Objectives: Acute toxicity is defined as the toxic effects produced by single exposure of drugs
by any route for a short period of time. These studies identify a single dose causing adverse
effects which cause lethality. The results of the acute toxicity study can also be used to
determine dosages in sub-acute toxicity studies. In the present study, modified Lorke's
method was used to determine acute toxicity. Methodology: Seventeen (17) Wistar rats were
used for the study. Twelve rats were grouped into two groups consisting of six rats each …

[PDF][PDF] Evaluation of acute oral toxicity induced by n-hexane extract of leptadenia hastata leaves on the histology of the pancreas and spleen in albino rats

A MOO, TW Jacks, SH Garba, K Anagor - 2019 - researchgate.net
Introduction: This study was undertaken to investigate the toxicological profile of the n-
hexane extract of Leptadenia hastata after acute administration on the histology of the
pancreas and spleen of albino rats. Methodology: A total of seventeen (17) albino rats were
used for the study. For the acute toxicity study, Lorke's method was adopted. Twelve rats
were grouped into two groups comprising of six rats each, which received a dosage of
10mg/kg, 100mg/kg and 1000mg/kg in the first phase. The second phase consisted of three …
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