Background aims Stem cell–based tissue regeneration offers potential for treatment of
craniofacial bone defects. The dental follicle, a loose connective tissue surrounding the
unerupted tooth, has been shown to contain progenitor/stem cells. Dental follicle stem cells
(DFSCs) have strong osteogenesis capability, which makes them suitable for repairing
skeletal defects. The objective of this study was to evaluate bone regeneration capability of
DFSCs loaded into polycaprolactone (PCL) scaffold for treatment of craniofacial defects …