Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit
FJ Gil-Bea, M García-Alloza, J Domínguez, B Marcos… - Neuroscience …, 2005 - Elsevier
Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have
been closely related to cholinergic deficits. We have compared different markers of
cholinergic function to assess the best biomarker of cognitive deficits associated to
cholinergic hypoactivity. In post-mortem frontal cortex from AD patients, acetylcholine (ACh)
levels, cholinacetyltransferase (ChAT) and acetylcholinesterase (AChE) activity were all
reduced compared to controls. Both ChAT and AChE activity showed a significant …
been closely related to cholinergic deficits. We have compared different markers of
cholinergic function to assess the best biomarker of cognitive deficits associated to
cholinergic hypoactivity. In post-mortem frontal cortex from AD patients, acetylcholine (ACh)
levels, cholinacetyltransferase (ChAT) and acetylcholinesterase (AChE) activity were all
reduced compared to controls. Both ChAT and AChE activity showed a significant …
Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit
Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have
been closely related to cholinergic deficits. We have compared different markers of
cholinergic function to assess the best biomarker of cognitive deficits associated to
cholinergic hypoactivity. In post-mortem frontal cortex from AD patients, acetylcholine (ACh)
levels, cholinacetyltransferase (ChAT) and acetylcholinesterase (AChE) activity were all
reduced compared to controls. Both ChAT and AChE activity showed a significant …
been closely related to cholinergic deficits. We have compared different markers of
cholinergic function to assess the best biomarker of cognitive deficits associated to
cholinergic hypoactivity. In post-mortem frontal cortex from AD patients, acetylcholine (ACh)
levels, cholinacetyltransferase (ChAT) and acetylcholinesterase (AChE) activity were all
reduced compared to controls. Both ChAT and AChE activity showed a significant …
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