The objective of this study was to evaluate the effect of multimodal analgesic drugs through cardiopulmonary, hormonal, metabolic and behavioral parameters for alleviation of pain perceived by goats during tube cystostomy. Sixteen bucks were randomly assigned into 4 groups 4 animals for each group. All bucks were received lidocaine hydrochloride 2% in a dose of 8 ml 15 minutes before surgery. Administration of meloxicam at dose of 0.5 mg/kg body weight took place before surgery on day 0 and was then repeated once daily for another 4 consecutive days postoperatively in groups Meloxicam-Butorphenol-Lidocaine (MBL), Meloxicam-Midazolam-Lidocaine (MML) and Meloxicam-Dexmedetomidine-Lidocaine (MDL). Heart rate (HR), respiratory rate (RR), rectal temperature (RT), serum concentrations of cortisol, interleukin-6 (IL-6), prostaglandin-E2 (PGE2) were determined at preset time intervals and the animals’ behavior was video recording, additionally detection of the effect of meloxicam on gastrointestinal bleeding using Hemo-Fec test was performed. Animals in MBL, MML and MDL groups showed good to excellent analgesia, a reduced vocalization and struggling. Mean HR, RR and RT were significantly reduced after dexmedetomidine treatment. Serum cortisol, IL-6 and PGE-2 levels remained significantly lower in dexmedetomidine treated animals compared to other groups. The use of dexmedetomidine and buterphanol in the analgesic protocol during tube cystostomy, alleviate stress and pain response and potentiate the analgesic effects of local analgesia. Addition of meloxicam to the analgesic protocol appears to be safe for the gastrointestinal tract and can be used for long term treatment of pain without complications.