Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C
G Esmat, M Metwally, KR Zalata, S Gadalla… - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: We evaluated whether surrogate serum biomarkers for liver injury are
comparable to liver biopsy in Egyptian patients with hepatitis C virus (HCV) infection.
SUBJECTS: Two hundred and twenty Egyptian patients, 91% infected with genotype-4 HCV,
undergoing liver biopsy during evaluation for interferon/ribavirin therapy. METHODS: Liver
biopsy scored by the Ishak method was compared to biochemical tests, platelet count and
two fibrosis biomarkers: hyaluronic acid (HA) and YKL-40. Univariate and logistic regression …
comparable to liver biopsy in Egyptian patients with hepatitis C virus (HCV) infection.
SUBJECTS: Two hundred and twenty Egyptian patients, 91% infected with genotype-4 HCV,
undergoing liver biopsy during evaluation for interferon/ribavirin therapy. METHODS: Liver
biopsy scored by the Ishak method was compared to biochemical tests, platelet count and
two fibrosis biomarkers: hyaluronic acid (HA) and YKL-40. Univariate and logistic regression …
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