Evaluation of systemic and brain pharmacokinetic parameters for repurposing metformin using intravenous bolus administration
Metformin's potential in treating ischemic stroke and neurodegenerative conditions is of
growing interest. Yet, the absence of established systemic and brain pharmacokinetic (PK)
parameters at relevant preclinical doses presents a significant knowledge gap. This study
highlights these PK parameters and the importance of using pharmacologically relevant
preclinical doses to study pharmacodynamics in stroke and related neurodegenerative
diseases. A liquid chromatography with tandem mass spectrometry method to measure …
growing interest. Yet, the absence of established systemic and brain pharmacokinetic (PK)
parameters at relevant preclinical doses presents a significant knowledge gap. This study
highlights these PK parameters and the importance of using pharmacologically relevant
preclinical doses to study pharmacodynamics in stroke and related neurodegenerative
diseases. A liquid chromatography with tandem mass spectrometry method to measure …
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