Evidence for anti-inflammatory effects of adalimumab in treatment of patients with major depressive disorder: A pilot, randomized, controlled trial
Background Literature has suggested that major depressive disorder (MDD) is accompanied
by higher concentrations of inflammatory biomarkers, which could sabotage response to
conventional treatments. Aims This study aimed to evaluate the efficacy and safety of
adalimumab adjunct to sertraline in adults with MDD and increased levels of systemic
inflammation. Methods In a 6-week, randomized, double-blind, placebo-controlled trial, 36
patients with MDD and high-sensitivity C-reactive protein≥ 3 mg/L were equally assigned to …
by higher concentrations of inflammatory biomarkers, which could sabotage response to
conventional treatments. Aims This study aimed to evaluate the efficacy and safety of
adalimumab adjunct to sertraline in adults with MDD and increased levels of systemic
inflammation. Methods In a 6-week, randomized, double-blind, placebo-controlled trial, 36
patients with MDD and high-sensitivity C-reactive protein≥ 3 mg/L were equally assigned to …
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