Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

AH Lee, SK Dhingra, IA Lewis, MK Singh… - Scientific reports, 2018 - nature.com
… to the global malaria elimination campaign. Specific mutations in the Plasmodium falciparum
… We also provide evidence that L272F confers a significant fitness cost to asexual blood …

Ion regulation in the malaria parasite

K Kirk - Annual review of microbiology, 2015 - annualreviews.org
intracellular parasite maintains tight control of its internal ion … negative charge arising from
the breakdown of hemoglobin (73). The … of Plasmodium EXP2 provides some evidence for this. …

Membrane transport in the malaria-infected erythrocyte

K Kirk - Physiological reviews, 2001 - journals.physiology.org
… the flux of solutes between the intraerythrocytic malaria … (eg, hemoglobin), while leaving
the intracellular parasite intact… evidence in support of the existence of parallel routes in the …

The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway

C Akkaya, E Shumilina, D Bobballa, VB Brand… - … -European Journal of …, 2009 - Springer
… channels in uninfected erythrocytes was taken as evidence … medium by intracellular ATP,
the hemoglobin concentration of … The Flux J of an ion by electrodiffusion is calculated with the …

A mathematical model of ion homeostasis in the malaria parasite, Plasmodium falciparum

J Diemer - 2023 - edoc.hu-berlin.de
Haemoglobin digestion commences in … intracellular ions), and the membrane potential.
Here I discuss the changes induced by an ion flux, before introducing the respective rate laws

Membrane transport in the malaria parasite and its host erythrocyte

K Kirk, AM Lehane - Biochemical Journal, 2014 - portlandpress.com
… host the malaria parasite takes up nutrients from the extracellularevidence for the activation
of endogenous erythrocyte ion … Adult human haemoglobin lacks isoleucine and the parasite …

The Homeostasis of Plasmodium falciparum-Infected Red Blood Cells

JMA Mauritz, A Esposito, H Ginsburg… - PLoS computational …, 2009 - journals.plos.org
… languid, hemoglobin-filled cell lacking intracellular organelles … evidence, but also a
progressive and large decline in its Hb … driving forces for passive ion fluxes across the host cell …

Ion and nutrient uptake by malaria parasite‐infected erythrocytes

SA Desai - Cellular microbiology, 2012 - Wiley Online Library
… cell volume and complete other activities through intracellular … for reproducible detection,
or ion flux and/or channel gating … findings as strong evidence for a single ion channel shared …

Regulation of Extracellular ATP in Human Erythrocytes Infected with Plasmodium falciparum

CL Alvarez, J Schachter, AA de Sa Pinheiro, LS Silva… - PloS one, 2014 - journals.plos.org
… Although the evidence above suggests that h-RBCs can act … glycolytic flux, which acts as
the sole source of intracellular ATP. … hemoglobin concentration would act as a major sink of the …

The Peculiarities and Paradoxes of Plasmodium Heme Metabolism

PA Sigala, DE Goldberg - Annual review of microbiology, 2014 - annualreviews.org
… , intracellular heme levels are stringently regulated, and heme … this proximity may facilitate
metabolic flux between these two … and chemical evidence that Plasmodium parasites do not …