Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)
Multidrug resistance protein 2 (MRP2) belongs to the ATP binding cassette family of
transporters. Its substrates include organic anions and anticancer drugs. We have used
transport assays with vesicles derived from Sf9 insect cells overproducing MRP2 to study the
interactions of drugs, organic anions, and bile acids with three MRP2 substrates: estradiol-
17-β-d-glucuronide (E 2 17βG), methotrexate, and glutathione-S-dinitrophenol. Complex
inhibition and stimulation patterns were obtained, different from those observed with the …
transporters. Its substrates include organic anions and anticancer drugs. We have used
transport assays with vesicles derived from Sf9 insect cells overproducing MRP2 to study the
interactions of drugs, organic anions, and bile acids with three MRP2 substrates: estradiol-
17-β-d-glucuronide (E 2 17βG), methotrexate, and glutathione-S-dinitrophenol. Complex
inhibition and stimulation patterns were obtained, different from those observed with the …
以上显示的是最相近的搜索结果。 查看全部搜索结果