Evolution of cefiderocol resistance in Stenotrophomonas maltophilia using in vitro serial passage techniques
BJ Werth, NK Ashford, K Penewit… - JAC-Antimicrobial …, 2022 - academic.oup.com
Objectives Cefiderocol is a siderophore cephalosporin active against MDR Gram-negatives
including Stenotrophomonas maltophilia. Cefiderocol resistance remains uncommon and
incompletely understood. We selected for cefiderocol-resistant S. maltophilia in vitro and
characterized the genetic mechanisms and potential for cross-resistance to other
antimicrobials. Methods We selected cefiderocol resistance in three clinical strains of S.
maltophilia by serial passage in escalating concentrations of cefiderocol. Emergent …
including Stenotrophomonas maltophilia. Cefiderocol resistance remains uncommon and
incompletely understood. We selected for cefiderocol-resistant S. maltophilia in vitro and
characterized the genetic mechanisms and potential for cross-resistance to other
antimicrobials. Methods We selected cefiderocol resistance in three clinical strains of S.
maltophilia by serial passage in escalating concentrations of cefiderocol. Emergent …
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