Ex vivo monitoring of human cytomegalovirus‐specific CD8+ T‐cell responses using QuantiFERON®‐CMV

S Walker, C Fazou, T Crough… - Transplant Infectious …, 2007 - Wiley Online Library
We have developed a novel diagnostic technology to monitor the human cytomegalovirus
(HCMV)‐specific CD8+ T‐cell responses that is based on the detection of secreted
interferon‐gamma (IFN‐γ) in the whole blood (referred to as QuantiFERON®‐CMV).
Evaluation of QuantiFERON®‐CMV in healthy individuals revealed that this technology was
at least as sensitive and with some HCMV epitopes more sensitive than the ELISPOT for
detecting ex vivo IFN‐γ. Results from QuantiFERON®‐CMV assays showed 97%(36/37 …
被引用次数：191 相关文章 所有 8 个版本

Ex vivo monitoring of human cytomegalovirus‐specific CD8+ T‐Cell responses using the QuantiFERON®‐CMV assay in allogeneic hematopoietic stem cell …

T Fleming, J Dunne, B Crowley - Journal of medical virology, 2010 - Wiley Online Library
Reconstitution of human cytomegalovirus (HCMV) T‐cell immunity is crucial in
hematopoietic stem cell transplant (HSCT) recipients. The QuantiFERON®‐CMV assay for
cellular HCMV‐specific immunity was evaluated in allogeneic HSCT recipients (n= 43) and
patients with hematological malignancies (n= 29) attending a tertiary‐care Irish hospital. An
intracellular cytokine (ICC) assay correlated with the QuantiFERON®‐CMV assay. Although
there was agreement between HCMV seropositivity and QuantiFERON®‐CMV assay, six …
被引用次数：41 相关文章 所有 10 个版本
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