PROJECT: The ob gene has either been found to be mutant defective resulting in a
deficiency of its product leptin or leptin has been found to be resistant to its receptors in
obese human and rodents. The factors inducing leptin resistance have not been identified.
Since excessive bioavailability of Zn has been implicated in obesity, we investigated if its
excess in diet induces leptin resistance. PROCEDURE: For the investigations, three groups
of Wistar rats were included in this study and they were fed on equicalories semi synthetic …