This paper highlights an investigation on the comparative analyses of exergetic performance with optimum volume concentration of hybrid nanofluids in a plate heat exchanger (PHE). Different types of hybrid nanofluids (Al 2 O 3+ MWCNT/water, TiO 2+ MWCNT/water, ZnO+ MWCNT/water, and CeO 2+ MWCNT/water) as coolant have been tested. Proportion of 0.75% of nanofluid has been found to be the optimum volume concentration. The requisite thermal and physical properties of the hybrid nanofluids were measured at 35 C. Various exergetic performance parameters have been examined for comparing different hybrid nanofluids. The highest reduction in exergy loss of CeO 2+ MWCNT/water hybrid nanofluid has been obtained at a concentration of about 24.75%. Entropy generation decreased with the increase in volume concentration. The results established that CeO 2+ MWCNT/water hybrid nanofluid can be a promising coolant for exergetic performances in a PHE.