Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal neuralgia

W Dong, SC Jin, A Allocco, X Zeng, AH Sheth… - IScience, 2020 - cell.com
… (GABRG1) exhibited trigeminal mechanical allodynia and face … exome-level insight into TN
and implicate genetically encoded impairment of GABA signaling and neuronal ion transport

Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia

S Manteniotis, R Lehmann, C Flegel, F Vogel… - PloS one, 2013 - journals.plos.org
… Using the Next Generation Sequencing technique (RNA-Seq), … Negri and colleagues
showed an impairment of nociception and … GABAergic signaling along with intracellular chloride …

Trigeminal neuralgia and genetics: A systematic review

MA Mannerak, A Lashkarivand, PK Eide - Molecular pain, 2021 - journals.sagepub.com
… of 2nd order neurons within the trigeminal brainstem sensory … channel subunits are activated
during GABA A R-mediated … been implicated in pain conditions mediated by the trigeminal

Role of omics in migraine research and management: a narrative review

P Chaturvedi, R Khan, P Sahu, A Ludhiadch… - Molecular …, 2022 - Springer
… and next-generation sequencing have … GABAergic inhibition is also known to regulate
catecholaminergic, serotoninergic, and glutamatergic neurons, which are involved in trigeminal

Ion channel mutations in neuronal diseases: a genetics perspective

OK Steinlein - Chemical Reviews, 2012 - ACS Publications
GABA A signaling constitutes the major inhibitory … of migraine, including the trigeminal
ganglion, the cortex, and the … the introduction of whole-genome sequencing as a routine method …

[HTML][HTML] The revolution in migraine genetics: from aching channels disorders to a next-generation medicine

S Pellacani, F Sicca, C Di Lorenzo… - Frontiers in Cellular …, 2016 - frontiersin.org
Next-generation sequencing (NGS) and more accurate and … are transmitted to the trigeminal
bipolar neurons, and further relayed, … activity due to impaired GABAergic inhibition (SCN1A), …

Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia

X Cui, B Qin, C Xia, H Li, Z Li, Z Li, A Nasir… - Frontiers in …, 2023 - frontiersin.org
… dorsal root ganglia primary sensory neurons. Non-coding RNAs (… genes were implicated in
neuropeptide signaling pathways. … to the musculus genome sequence (version GRCm38.72). …

Integration of single-nucleus RNA sequencing and network disturbance to elucidate crosstalk between multicomponent drugs and trigeminal ganglia cells in migraine

B Zhang, Y Xi, Y Huang, Y Zhang, F Guo… - Journal of …, 2024 - Elsevier
… synaptic transmission, and green represents ion transport). (For … response, synaptic
signalling, and ion transport. This may … C1, C3, and C8 mainly disturbed the non-neuronal cell …

Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia

ER Mustafá, E Gambeta, RN Stringer, IA Souza… - Molecular Brain, 2022 - Springer
… Recently, whole exome sequencing analysis of familial TN … Ca v 3.2 variants on neuronal
electrical activities using a … has been implicated in the development of trigeminal pain [14]. …

The pathophysiology of trigeminal neuralgia: a molecular review

B Dong, R Xu, M Lim - Journal of neurosurgery, 2023 - thejns.org
… and molecular pathways implicated in orofacial pain signaling in TG neurons in human …
Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal