Expanded HILUS trial: a pooled analysis of risk factors for toxicity from stereotactic body radiation therapy of central and ultracentral lung tumors
S Lindberg, V Grozman, K Karlsson, E Onjukka… - International Journal of …, 2023 - Elsevier
Purpose Stereotactic body radiation therapy for tumors near the central airways implies high-
grade toxic effects, as concluded from the HILUS trial. However, the small sample size and
relatively few events limited the statistical power of the study. We therefore pooled data from
the prospective HILUS trial with retrospective data from patients in the Nordic countries
treated outside the prospective study to evaluate toxicity and risk factors for high-grade toxic
effects. Methods and Materials All patients were treated with 56 Gy in 8 fractions. Tumors …
grade toxic effects, as concluded from the HILUS trial. However, the small sample size and
relatively few events limited the statistical power of the study. We therefore pooled data from
the prospective HILUS trial with retrospective data from patients in the Nordic countries
treated outside the prospective study to evaluate toxicity and risk factors for high-grade toxic
effects. Methods and Materials All patients were treated with 56 Gy in 8 fractions. Tumors …
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