Expansion of IL-6+ Th17-like cells expressing TLRs correlates with microbial translocation and neurological disabilities in NMOSD patients
PO Barros, ASO Dias, TM Kasahara… - Journal of …, 2017 - Elsevier
Different microbial antigens, by signaling through toll-like receptors (TLR), may contribute to
Th17-mediated autoimmune diseases, such as neuromyelitis optica spectrum disorder
(NMOSD). The objective of this study was to determine the proportion of different Th17-like
cell subsets that express TLR in NMOSD patients. For this study, the frequency of different
Th17 cell subsets expressing TLR subsets in healthy individuals (n= 20) and NMOSD
patients (n= 20) was evaluated by cytometry. The peripheral levels of soluble CD14 (sCD14) …
Th17-mediated autoimmune diseases, such as neuromyelitis optica spectrum disorder
(NMOSD). The objective of this study was to determine the proportion of different Th17-like
cell subsets that express TLR in NMOSD patients. For this study, the frequency of different
Th17 cell subsets expressing TLR subsets in healthy individuals (n= 20) and NMOSD
patients (n= 20) was evaluated by cytometry. The peripheral levels of soluble CD14 (sCD14) …