Expediting disulfiram assays through a systematic analytical quality by design approach
An Analytical Quality by Design (AQbD) approach is presented, aiming at the development
and validation of an HPLC method for the quantification of disulfiram and copper
diethyldithiocarbamate in lipid nanoparticles. Following the definition of the analytical target
profile (ATP), encompassing the critical analytical attributes (CAA), a two-level risk
assessment strategy (Ishikawa diagram—failure mode and effect analysis (FMEA)) was
employed to identify the critical method parameters (CMPs) with an extensive impact on …
and validation of an HPLC method for the quantification of disulfiram and copper
diethyldithiocarbamate in lipid nanoparticles. Following the definition of the analytical target
profile (ATP), encompassing the critical analytical attributes (CAA), a two-level risk
assessment strategy (Ishikawa diagram—failure mode and effect analysis (FMEA)) was
employed to identify the critical method parameters (CMPs) with an extensive impact on …
[PDF][PDF] Expediting Disulfiram Assays through a Systematic Analytical Quality by Design Approach. Chemosensors 2021, 9, 172
An Analytical Quality by Design (AQbD) approach is presented, aiming at the development
and validation of an HPLC method for the quantification of disulfiram and copper
diethyldithiocarbamate in lipid nanoparticles. Following the definition of the analytical target
profile (ATP), encompassing the critical analytical attributes (CAA), a two-level risk
assessment strategy (Ishikawa diagram—failure mode and effect analysis (FMEA)) was
employed to identify the critical method parameters (CMPs) with an extensive impact on …
and validation of an HPLC method for the quantification of disulfiram and copper
diethyldithiocarbamate in lipid nanoparticles. Following the definition of the analytical target
profile (ATP), encompassing the critical analytical attributes (CAA), a two-level risk
assessment strategy (Ishikawa diagram—failure mode and effect analysis (FMEA)) was
employed to identify the critical method parameters (CMPs) with an extensive impact on …
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