The current study focuses on an experimental investigation of upward vertical two-phase flow of binary mixtures in complex geometries composed of offset-strip fins. The flow boiling of a mixture containing 52% mol/mol of R-134a and 48% mol/mol of R-245fa was visualized. The ranges of mass flux and heat flux investigated were 11–25 kg. m− 2. s− 1 and 9–23 kW. m− 2 respectively. The test section is an offset-strip finned passage whose hydraulic diameter is 1.75 mm. The operating pressure ranges from 2 to 5 bar absolute. The temperature glide of the used binary mixture ranges from 14 to 16° C. Different flow regimes were identified along the test section such as bubbly, slug and annular regimes. The impact of strip-fins and mass flux on flow maps was analysed in this study. The pressure drop was analyzed and the obtained data were gathered to propose a new correlation for R-134a/R-245fa mixture in offset-strip fins. The local heat transfer coefficient was calculated and it has been found that nucleate boiling was the predominant mode of heat transfer.