Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1
VD Atayde, A da Silva Lira Filho, V Chaparro… - Nature …, 2019 - nature.com
Leishmania are ancient eukaryotes that have retained the exosome pathway through
evolution. Leishmania RNA virus 1 (LRV1)-infected Leishmania species are associated with
a particularly aggressive mucocutaneous disease triggered in response to the double-
stranded RNA (dsRNA) virus. However, it is unclear how LRV1 is exposed to the
mammalian host cells. In higher eukaryotes, some viruses are known to utilize the host
exosome pathway for their formation and cell-to-cell spread. As a result, exosomes derived …
evolution. Leishmania RNA virus 1 (LRV1)-infected Leishmania species are associated with
a particularly aggressive mucocutaneous disease triggered in response to the double-
stranded RNA (dsRNA) virus. However, it is unclear how LRV1 is exposed to the
mammalian host cells. In higher eukaryotes, some viruses are known to utilize the host
exosome pathway for their formation and cell-to-cell spread. As a result, exosomes derived …
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