In this paper we present SYNAISTHISI, i.e., a cloud-based platform, that provides the necessary infrastructure in order to interconnect heterogeneous devices and services over heterogeneous networks. SYNAISTHISI facilitates the orchestration of a collective functionality allowing several services to be managed through agents that dynamically allocate the available resources.. In a smart room use-case, multiple sensing and actuation units have been developed and deployed in a lecture room. Maintaining comfort levels for room occupants is achieved through automatic decision making that exploits information from a complex event recognition engine. Our goal is to improve the overall working environment, while minimizing energy losses.