Exploring possibility of promiscuity of amyloid inhibitor: Studies on effect of selected compounds on folding and amyloid formation of proteins
Fibrillar protein aggregates called amyloids are the hallmark of several degenerative
diseases. Identification of common drugs which are capable of blocking or inhibiting protein
aggregation may be considered as one of the therapeutic approaches directed against
amyloid diseases. The present study describes the effect of a few small molecule
compounds like clotrimazole, sulconazole and rottlerin towards amyloidogenesis of two
model proteins unrelated in terms of structure and sequence such as hen egg white …
diseases. Identification of common drugs which are capable of blocking or inhibiting protein
aggregation may be considered as one of the therapeutic approaches directed against
amyloid diseases. The present study describes the effect of a few small molecule
compounds like clotrimazole, sulconazole and rottlerin towards amyloidogenesis of two
model proteins unrelated in terms of structure and sequence such as hen egg white …
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