Expression and purification of a new recombinant camel hepcidin able to promote the degradation of the iron exporter ferroportin1
M Boumaiza, M Jaouen, JC Deschemin… - Protein Expression and …, 2015 - Elsevier
Abstract Hepcidin, a 25-amino-acid and highly disulfide bonded antimicrobial peptide, is the
central regulator of iron homeostasis. This hormone is expressed in response to iron and
inflammation and interacts with ferroportin1 (FPN1), the only known iron exporter in
vertebrates, inducing its internalization and degradation. Thus, the export of iron from cells to
plasma will be significantly diminished. Thereby, hepcidin has become the target of intense
research studies due to its profound biomedical significance. This study describes the …
central regulator of iron homeostasis. This hormone is expressed in response to iron and
inflammation and interacts with ferroportin1 (FPN1), the only known iron exporter in
vertebrates, inducing its internalization and degradation. Thus, the export of iron from cells to
plasma will be significantly diminished. Thereby, hepcidin has become the target of intense
research studies due to its profound biomedical significance. This study describes the …
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