Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium
VS Ratts, XJ Tao, CB Webster, PE Swanson, SD Smith… - Placenta, 2000 - Elsevier
The regulation of apoptosis in the syncytiotrophoblast is of particular interest because this is
the only true syncytial epithelium in human cell biology. Nuclei characteristic of apoptotic
cells have been localized to this syncytium especially in association with fibrin-containing
fibrinoid deposits. The factors responsible for regulating cell death-like features in the
trophoblast syncytium are unknown. We tested the hypothesis that fibrin was required for
trophoblast apoptosis. TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP end …
the only true syncytial epithelium in human cell biology. Nuclei characteristic of apoptotic
cells have been localized to this syncytium especially in association with fibrin-containing
fibrinoid deposits. The factors responsible for regulating cell death-like features in the
trophoblast syncytium are unknown. We tested the hypothesis that fibrin was required for
trophoblast apoptosis. TUNEL (terminal deoxynucleotidyltransferase-mediated dUTP end …
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