Expression of C19MC miRNAs in HCC associates with stem-cell features and the cancer-testis genes signature
C Augello, F Colombo, A Terrasi, E Trombetta… - Digestive and Liver …, 2018 - Elsevier
Background Intratumor heterogeneity of hepatocellular carcinoma (HCC) and, among HCC
cell subsets, the cancer stem cell population (hCSC), is responsible for therapeutic
resistance and disease relapse. Aims To characterize hCSC-enriched HCCs at the
molecular level. Methods Side population (SP) was used to identify the hCSCs in multiple
tumor sampling from different patients and primary HCCs cultures. FACS was used to
immunoprofile cultures. miRNAs were profiled in samples and correlated to SP. The Cancer …
cell subsets, the cancer stem cell population (hCSC), is responsible for therapeutic
resistance and disease relapse. Aims To characterize hCSC-enriched HCCs at the
molecular level. Methods Side population (SP) was used to identify the hCSCs in multiple
tumor sampling from different patients and primary HCCs cultures. FACS was used to
immunoprofile cultures. miRNAs were profiled in samples and correlated to SP. The Cancer …
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