Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: an immunohistochemical study and analysis of prognostic value
BACKGROUND: The mitogen-activated protein kinase (MAPK) signaling pathway is one of
the major cascades that are crucial for the initiation and progression of melanoma; however,
the influence of these signaling molecules on patient survival has not been clarified.
OBJECTIVE: The purpose of this study was to analyze the protein expression of MAPK
signaling molecules in melanoma, and to correlate the expression status with
clinicopathologic parameters. METHODS: Expression of c-Kit, phosphorylated ERK (p-ERK) …
the major cascades that are crucial for the initiation and progression of melanoma; however,
the influence of these signaling molecules on patient survival has not been clarified.
OBJECTIVE: The purpose of this study was to analyze the protein expression of MAPK
signaling molecules in melanoma, and to correlate the expression status with
clinicopathologic parameters. METHODS: Expression of c-Kit, phosphorylated ERK (p-ERK) …
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