Extemporaneous formulations of metformin for pediatric endocrinology: physicochemical integrity, cytotoxicity of sweeteners, and quantitation of plasma levels
R Alemón-Medina, JL Chávez-Pacheco… - Clinical …, 2015 - Elsevier
Purpose In response to the lack of pediatric formulations of metformin to control type 2
diabetes mellitus, hyperinsulinemic obesity, and dyslipidemias, we developed liquid
formulations of metformin by dissolving 3 generic brands of 500-mg metformin*,†,‡ tablets in
water sweetened with sucralose. The physicochemical stabilities of these drugs were
assessed and compared with those of formulations made with the innovative brand of
metformin.∥ A method to measure metformin plasma levels was proposed and then tested …
diabetes mellitus, hyperinsulinemic obesity, and dyslipidemias, we developed liquid
formulations of metformin by dissolving 3 generic brands of 500-mg metformin*,†,‡ tablets in
water sweetened with sucralose. The physicochemical stabilities of these drugs were
assessed and compared with those of formulations made with the innovative brand of
metformin.∥ A method to measure metformin plasma levels was proposed and then tested …
Extemporaneous Formulations of Metformin for Pediatric Endocrinology: Physicochemical Integrity, Cytotoxicity of Sweeteners, and Quantitation of Plasma Levels
A Medina Radamés - 2019 - repositorio.pediatria.gob.mx
Purpose In response to the lack of pediatric formulations of metformin to control type 2
diabetes mellitus, hyperinsulinemic obesity, and dyslipidemias, we developed liquid
formulations of metformin by dissolving 3 generic brands of 500-mg metformin∗, â€, ‡
tablets in water sweetened with sucralose. The physicochemical stabilities of these drugs
were assessed and compared with those of formulations made with the innovative brand of
metformin. a A method to measure metformin plasma levels was proposed and then tested …
diabetes mellitus, hyperinsulinemic obesity, and dyslipidemias, we developed liquid
formulations of metformin by dissolving 3 generic brands of 500-mg metformin∗, â€, ‡
tablets in water sweetened with sucralose. The physicochemical stabilities of these drugs
were assessed and compared with those of formulations made with the innovative brand of
metformin. a A method to measure metformin plasma levels was proposed and then tested …
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