Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data

EH Jho, J An, K Nam - Environmental Toxicology and …, 2011 - Wiley Online Library
The combined toxic effects of Cd and Pb in the presence of different concentrations of Ca2+
were predicted using the biotic ligand model (BLM), with the parameters derived from the Cd‐
only and Pb‐only toxicity data. The BLM‐based toxic unit (TU) approach and the proposed
BLM‐based fmix approach were used for prediction. The predicted mixture toxic effects
using the BLM‐based fmix approach were closer to the observed mixture effects (root mean
square error [RMSE]= 9.7 at 25 mM Ca2+) than that using the BLM‐based TU approach …

Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data.

JEH Jho EunHea, AJS An JinSung… - 2011 - cabidigitallibrary.org
The combined toxic effects of Cd and Pb in the presence of different concentrations of Ca2+
were predicted using the biotic ligand model (BLM), with the parameters derived from the Cd-
only and Pb-only toxicity data. The BLM-based toxic unit (TU) approach and the proposed
BLM-based f mix approach were used for prediction. The predicted mixture toxic effects
using the BLM-based f mix approach were closer to the observed mixture effects (root mean
square error [RMSE]= 9.7 at 25 mM Ca2+) than that using the BLM-based TU approach …
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