Extended ischemia prevents HIF1α degradation at reoxygenation by impairing prolyl-hydroxylation: Role of krebs cycle metabolites
A Serra-Pérez, AM Planas, A Núñez-O'Mara… - Journal of Biological …, 2010 - ASBMB
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that activates the
cellular response to hypoxia. The HIF1α subunit is constantly synthesized and degraded
under normoxia, but degradation is rapidly inhibited when oxygen levels drop. Oxygen-
dependent hydroxylation by prolyl-4-hydroxylases (PHD) mediates HIF1α proteasome
degradation. Brain ischemia limits the availability not only of oxygen but also of glucose. We
hypothesized that this circumstance could have a modulating effect on HIF. We assessed the …
cellular response to hypoxia. The HIF1α subunit is constantly synthesized and degraded
under normoxia, but degradation is rapidly inhibited when oxygen levels drop. Oxygen-
dependent hydroxylation by prolyl-4-hydroxylases (PHD) mediates HIF1α proteasome
degradation. Brain ischemia limits the availability not only of oxygen but also of glucose. We
hypothesized that this circumstance could have a modulating effect on HIF. We assessed the …
以上显示的是最相近的搜索结果。 查看全部搜索结果